The Chemical Educator,
Vol. 5, No. 3, S1430-4171(00)03388-2,
10.1007/s00897000388a, © 2000 Springer-Verlag New York, Inc.
I Wish I’d Made
You Angry Earlier: Essays on Science, Scientists, and Humanity. By
Max F. Perutz. Cold Spring Harbor Laboratory Press: 10 Skyline Drive, Plainview,
NY 11803-2500, 1998. Figures. xv + 354 pp. 16.0 ´ 23.3 cm. $39.00. ISBN 0-87969-524-2.
Reviewed
by: George B. Kauffman and Laurie
M. Kauffman, California State University, Fresno, george_kauffman@csufresno.edu
As frequent book reviewers, we particularly enjoyed this fascinating collection of essays (22 of which are book reviews) by Max Ferdinand Perutz, the Austrian-born British biochemist who shared the 1962 Nobel Prize for Chemistry with John C. Kendrew for X-ray diffraction analysis of the structure of hemoglobin. In his preface to this well-chosen selection he describes hemoglobin as his “mistress.” The reviews transcend the genre and can be read with pleasure as independent essays. The book is suitable for both browsing and for careful reading
Perutz
was Director of the Medical Research Council Laboratory for Molecular Biology,
Cambridge, England from its establishment in 1962 until 1979, and he remains a
scientific staff member. To date nine MRC-LMB staff members have received ten
Nobel prizes, and Perutz muses on the factors underlying such creativity. He
concludes that:
“Creativity in science as in the
arts, cannot be organised. It arises spontaneously from individual talent.
Well-run laboratories can foster it, but hierarchical organisation, inflexible,
bureaucratic rules, and mountains of futile paperwork can kill it. Discoveries
cannot be planned; they pop up, like Puck, in unexpected corners.”
Allusions
to literary and classical characters abound in Perutz’s essays and bear witness
to his status as a true Renaissance man. In this collection creativity is only
one of numerous scientific themes that are discussed with the same lucidity and
precision that characterize Perutz’s pioneering work in crystallography.
Perutz’s
book contains 28 essays, all but one of which were originally published during
the period 1968–1997 in slightly different forms and mostly under different
titles. Eleven appeared in The New York
Review of Books, three each in London
Review of Books and Nature, and
one each in Nature Structural Biology,
The Scientist, Gene, The Times Higher
Education Supplement, New Scientist,
The Independent, Proceedings of the American Philosophical Society, Scientific American, and International Union of Crystallography.
The
book is divided into four sections; the selections in the first three were
written for nonscientists and consequently presuppose no scientific knowledge.
Those in the last section were addressed to scientists and may be more
difficult for laypersons to follow. The essays explore a remarkable range of
scientific topics, and, replete with amusing and insightful anecdotes, they
profile many of Perutz’s favorite scientists, some of whom he knew personally.
The contents give some idea of the scope of the volume.
I. “Plowshares into Swords”
“Friend
or Foe of Mankind?” (Fritz Haber, “a man’s fascination with poison gas”)
“Splitting
the Atom” (Lise Meitner)
“The
Man Who Patented the Bomb” (Leo Szilard, who, before his flight from Europe,
“always lived with two packed suitcases, in case he had to flee from wherever
he happened to be”)
“Why
Did the Germans Not Make the Bomb?” (Werner Heisenberg)
“Bomb
Designer Turned Dissident” (Andrei Sakharov)
“Liberating
France” (François Jacob)
“Enemy
Alien” (the book’s longest essay and the only one that had not been previously
published. It recounts Perutz’s multifarious experiences as one of numerous
German and Austrian refugees who were paradoxically classified as “enemy
aliens” (the camp commander said, “I had no idea there were so many Jews among
the Nazis.”) and consequently imprisoned on the Isle of Man and then deported
to Canada. Perutz eventually made his way back to Britain, where he remained.)
II. “How to Make
Discoveries”
“High
on Science” (Peter Medawar)
“Deconstructing
Pasteur” (a convincing critique of Gerald L. Geison’s revisionist biography)
“The
Battle Over Vitamin C” (Albert Szent-Györgyi)
“A
Mystery of the Tropics” (malaria and tropical diseases)
“The
Forgotten Plague” (tuberculosis)
“What
Holds Molecules Together?” (obituary of Linus Pauling)
“I
Wish I’d Made You Angry Earlier” (The book’s title essay. Perutz had shown his
mentor W. L. Bragg his X-ray diffraction results confirming Linus Pauling and Robert
B. Corey’s a-helix model for a-keratin and stated that the idea for the experiment was sparked by his
fury at missing the structure himself. Bragg replied, “‘I wish I’d made you
angry earlier!’ because discovery of the 1.5-Å reflection would have led us
straight to the a-helix.”)
“Big
Fleas Have Little Fleas...” (Max Delbrück)
“How
the Secret of Life Was Discovered” (“From the Double Helix to the Human Genome:
40 Years of Molecular Genetics,” cochairman’s remarks at a UNESCO symposium)
“Dangerous
Misprints” (screening for genetic diseases)
“A
Deadly Inheritance” (Harvard pediatrician David G. Nathan and thalassemia, a
genetic disease resulting in defective synthesis of hemoglobin)
“Darwin
Was Right” (a new view of evolution)
“A
Passion for Crystals” (obituary of Dorothy Crowfoot Hodgkin, who “radiated
motherly warmth even while doing scientific work;” LMK’s favorite essay)
III. “Rights and Wrongs”
“By
What Right Do We Invoke Human Rights?” (the collection’s only nonscientific
essay)
“The
Right to Choose” (Carl Djerassi and the contraceptive pill)
“Swords
into Plowshares: Does Nuclear Energy Endanger Us?” (Britain, the welfare state,
and nuclear proliferation)
IV. “More About Discoveries”
“The
Second Secret of Life” (the structure of hemoglobin and respiratory transport)
“How
W. L. Bragg Invented X-ray Analysis”
“Life’s
Energy Cycle” (Hans Krebs and the ornithine and citric acid cycles)
“The
Hormone that Makes Nerves Grow” (Rita Levi-Montalcini and the nerve growth
factor, 3 pp, the collection’s shortest essay)
“How
Nerves Conduct Electricity” (Alan Hodgkin and Andrew Huxley)
A
“Photo Gallery” includes 23 formal and informal portraits of some of the
scientists featured in the book. As an inveterate collector of quotations and a
frequent user of such pithy sayings in writings and lectures, one of us (GBK)
was particularly entranced by Perutz’s 19-page classified appendix of wise
sayings, “My Commonplace Book,” a name that goes back to antiquity when Greek
and Roman orators collected metaphors to be used for speeches in public places.
Thirteen pages of notes and references (ranging in time from Thucydides and
Marcus Aurelius to 1996) and a 12-page (double-column) subject index conclude
the volume.
Unfortunately,
this otherwise error-free book is marred by a number of typographical
misspellings, especially in proper names. Many of these were probably
introduced by editors in compiling the index and do not appear in the original
essays, e.g., Berthollet not Berthelot (C. L.) (pp 5, 344), Walther not Walter (Nernst) (pp 11, 349), Frédéric
not Frederic Joliot (pp 26, 348), Mill not Mills (John Stuart) (pp 225, 226), Dirk not Dick (Coster) (p
345), Irène not Irene (Curie) (p 345), and Stoltzenberg
not Stolzenberg (p 352). Also, nouns
are not capitalized in the German title of Hahn and Strassmann’s classic
article on nuclear fission (p 330).
According
to Nobel Laureate Peter Medawar (physiology or medicine, 1960), one of the many
scientists profiled in this book, “science at all levels of endeavour is a
passionate enterprise and the pursuit of natural knowledge a sortie into the
unknown.” Perutz’s book, which we heartily recommend to scientist and
nonscientist alike, will convince its readers of the truth of this statement.