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The Chemical Educator

ISSN: 1430-4171 (electronic version)

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Abstract Volume 6 Issue 2 (2001) pp 100-103

Design of a Drug-Delivery System Based On Polyacrylamide Hydrogels. Evaluation of Structural Properties

L. Ferreira, M. M. Vidal,* and M. H. Gil

Departamento de Engenharia Química, Universidade de Coimbra* Pinhal de Marrocos, 3030 Coimbra, Portugal*, and Escola Superior Agrária de Coimbra, 3000 Coimbra, Portugal
Received October 2, 2000. Accepted December 12, 2000

Published online: 16 February 2001

Abstract. It is well known that hydrogels can be suitable for biomedical, agricultural, and industrial applications. In particular, they have been widely used for the preparation of drug- delivery systems. The preparation and characterization of such a system should be useful for introducing students to these materials. This paper describes the preparation of polyacrylamide hydrogels having different crosslinking densities from the view of optimizing this system for acetylsalicylic acid (aspirin) release. The observations of equilibrium swelling, solute transport, and thermal analysis are related to the network structure of polyacrylamide hydrogel.

Key Words:  Laboratories and Demonstrations; polymer chemistry; thermal analyses; drugs; pharmaceuticals; hydrogels; polyacrylamide

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Issue date: April 6, 2001

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