TCE     
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The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 6
Issue 2 (2001) pp 100-103
Design of a Drug-Delivery System Based On Polyacrylamide Hydrogels. Evaluation of Structural Properties
L. Ferreira, M. M. Vidal,* and M. H. Gil
Departamento de Engenharia Química, Universidade de Coimbra* Pinhal
de Marrocos, 3030 Coimbra, Portugal*, and Escola Superior Agrária
de Coimbra, 3000 Coimbra, Portugal
Received October 2, 2000. Accepted December 12, 2000
Published online: 16 February 2001
Abstract. It is well
known that hydrogels can be suitable for biomedical, agricultural, and
industrial applications. In particular, they have been widely used for
the preparation of drug- delivery systems. The preparation and characterization
of such a system should be useful for introducing students to these materials.
This paper describes the preparation of polyacrylamide hydrogels having
different crosslinking densities from the view of optimizing this system
for acetylsalicylic acid (aspirin) release. The observations of equilibrium
swelling, solute transport, and thermal analysis are related to the network
structure of polyacrylamide hydrogel.
Key Words: Laboratories and Demonstrations; polymer chemistry; thermal analyses; drugs; pharmaceuticals; hydrogels; polyacrylamide
(*) Corresponding author. (E-mail: mariavidal10@hotmail.com)
Article in PDF format (182 KB) HTML format
Issue date: April 6, 2001
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