Preparation of Azo Dyes from Sulfanilamide

TCE

The Chemical Educator

ISSN: 1430-4171 (electronic version)

Table of Contents

Abstract Volume 9 Issue 2 (2004) pp 89-90

Preparation of Azo Dyes from Sulfanilamide

Kathleen Alfare,^† David Lee,^† Eric Scharrer,^‡ and Scott A. Van Arman*^,^†

^†Department of Chemistry, Franklin and Marshall College, Lancaster, PA 17604-3003, scott.vanarman@fandm.edu and ^‡Department of Chemistry, University of Puget Sound, Tacoma, WA 98416
Received January 8, 2004. Accepted March 2, 2004.

Published online: 9 March 2004

Abstract. A synthesis of a library of potential antibiotic azo dyes is described starting ultimately from aniline and directly from sulfanilamide. The procedure is analogous to that for the preparation of the historically important antibiotic azo dye, Prontosil.

Key Words: Laboratories and Demonstrations; organic chemistry; organic synthesis; dyes; drugs; bismuth

(*) Corresponding author. (E-mail: scott.vanarman@fandm.edu)

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Supporting Materials:

Detailed instructions for students, including safety warnings, and instructor’s notes, which include suggestions for recrystallization of the products, are available in a Zip file as supporting material (146 KB).