The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 11
Issue 2 (2006) pp 93-97
The Multistep Synthesis of a Chiral Aromatic Oxazoline (An Intermediate in the Synthesis of the Antibiotic Cytosporone E): An Advanced Undergraduate Laboratory Experience
Justin K. Wyatt,* Christopher L. Bolton, Marie C. Correia, and Caroline M. Watson
Department of Chemistry and Biochemistry, College
Charleston, 66 George Street, Charleston, SC 29424, firstname.lastname@example.org
Published online: 22 February 2006
Abstract. An advanced organic chemistry laboratory for undergraduate students is described. The multistep synthesis is broken down into two parts. The overall four-step reaction sequence starts with L-valine and ends with a chiral aromatic oxazoline maintaining the integrity of the chiral amino acid. This is intended to be a “research-type” laboratory experience to introduce students to the process of conducting research.
Key Words: Laboratories and Demonstrations; organic chemistry; synthesis
(*) Corresponding author. (E-mail: email@example.com)
Two supporting files are available. One contains the student assignments and handouts and the other contains the spectra. They may be downloaded in a Zip file (343 KB).
Issue date: April