The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 14
Issue 2 (2009) pp 52-54
Structure-Antioxidant Activity of p-Coumaric Acid Analogs
Leticia U. Colmenares,* Shirley Young-Robbins,† and Alfred E. Asato‡
Natural Science Department, University of Hawaii-Windward,
Science Department Kaneohe, HI, 96744, firstname.lastname@example.org and Chemistry
Department, University of Hawaii-Manoa, Honolulu, HI 96822
Published online: 1 April 2009
Abstract. A series of p-coumaric acid analogs, 3-substituted 4-hydroxycinnamic acids with electron-withdrawing (II: 3-NO2, III: 3-F) and electron-donating (IV: 3-CH3, V: 3-OCH3) substituents are utilized to demonstrate the relationship between their chemical structures and antioxidant properties. Using the ABTS/HRP/H2O2 method, the relative decolorization concentration DC50 (dose to scavenge 50% of the free radical) for I-V were determined and found to correlate with electronic substituent effects.
Key Words: Laboratories and Demonstrations; first-year undergraduate/general to upper-division undergraduate; organic chemistry; substitutent effect; antioxidant activity; coumaric acids; phenols; spectrophotometry
(*) Corresponding author. (E-mail: email@example.com)
Supporting Materials:Details of the experiment including safety information are available in the supporting materPreparation and 1H-NMR data of p-coumaric acid derivatives (I-IV) and detailed student results of antioxidant activity determination are included in the supporting material (120 KB).
Issue date: April