The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 15
(2010) pp 469-470
Commercial Vitamin A Capsules: Is There Any Retinol?
Ignacio Fernández*,†, David Arraez-Román‡
†Área de Química Orgánica and NMR Facility at Servicios
Centrales de Investigación, Universidad de Almería, Carretera de Sacramento,
s/n, E-04120, Almería, Spain; firstname.lastname@example.org; ‡Department of Analytical
Chemistry, Faculty of Science, University of Granada, C/Fuentenueva
s/n, E-18071, Granada, Spain
Published: 31 December 2010
Abstract. The experiment introduces hands-on 1D and 2D NMR analysis of vitamin A capsules, without the use of any chromatographic purification or extraction step. Among the different species deduced from the NMR spectra, the students conclude with the lackness of any retinol in the tablets analyzed. This laboratory exercise is used to introduce the students to organic spectroscopic techniques and to show them that NMR is not simply a means to elucidate structures of pure compounds but that it can be used to analyze more complex mixtures.
Key Words: Laboratories and Demonstrations; organic chemistry; NMR
(*) Corresponding author. (E-mail: email@example.com)
Supporting Materials:Available is a PDF file including experimental details, synthetic procedures, and some key notes that the students may follow to achieve the structural determinations (262 KB).