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The Chemical Educator

ISSN: 1430-4171 (electronic version)

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Abstract Volume 15 (2010) pp 479-483

Capecitabine: A Classroom Project for the Study of General Principles in Organic Synthesis

Ana Alcudia, Cristina Ferris, and María Violante de Paz*

Dpto. Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012-Sevilla, Spain.
Received July 6, 2010. Accepted September 2, 2010.

Published: 31 December 2010

Abstract. The extent of Organic Chemistry has critical impact today on teaching Advanced Medicinal Chemistry. In this paper, an alternative approach to learn retrosynthetic analysis through problem solving and collaborative learning is presented. Thus, an anticancer drug, Capecitabine (Xeloda) is used to illustrate the potential of Problem Based Learning (PBL) methodologies. Compiled data are evaluated under the light of case study to show up the relevance of these experiences in the development of new student skills.

Key Words: In the Classroom; organic chemistry; capecitabine, xeloda, PBL, retrosynthesis

(*) Corresponding author. (E-mail:

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