The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 16
(2011) pp 89-90
Electrophilic Aromatic Chlorination: Synthesis of the Fungicide Chloroneb
Gary W. Breton
Berry College, Department of Chemistry, PO Box 495016,
Mount Berry, GA 30149 firstname.lastname@example.org
Published: 18 March 2011
Abstract. A convenient laboratory synthesis of the widely-used fungicide Chloroneb (i.e., 1,4-dichloro-2,5-dimethoxybenzene) is described. The experiment illustrates the practical utility of the synthetically important process of electrophilic aromatic substitution. The electrophile, chlorine, is generated in-situ via the reaction of calcium hypochlorite with acetic acid. The Chloroneb product is obtained in yields averaging 37%.
Key Words: Laboratories and Demonstrations; organic chemistry; synthesis
(*) Corresponding author. (E-mail: email@example.com)
Supporting Materials:Equipment list, chemicals and CAS registry numbers, safety and hazard notes, instructor notes, student lab experiment hand-out, 1H NMR and IR spectra of the product (919 KB).