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The Chemical Educator

ISSN: 1430-4171 (electronic version)

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Abstract Volume 17 (2012) pp 068-070
DOI 10.1007/s00897122417a

Electroanalysis of Chlorpromazine (CPZ) Utilizing Cetyltrimethylammonium Bromide Carbon Paste Electrode (CTABCPE)

Urmimala Chaudhuri, Miyong Hughes and Suzanne K. Lunsford*Mara Bertrand Campos de Araujo,Marina Teixeira Laranjo and Suzana Trindade Amaral*

Wright State University, Department of Chemistry, 3640 Colonel Glenn Hwy., Dayton, OH 45435, Suzanne.Lunsford@wright.edu
Received November 21, 2011. Accepted April 29, 2012.

Published: 11 May 2012

Abstract. An undergraduate laboratory experiment for inorganic /electroanalytical chemistry is described utilizing an everyday surfactant as a sensor. A cation surfactant Cetyltrimethylammonium Bromide (CTAB) modified carbon paste electrode was fabricated and applied to detection of chlorpromazine (CPZ). CPZ is used in the management of psychotic conditions for patients and it is of primary importance to learn alternative method for detection of CPZ. The Cetyltrimethylammonium Bromide Carbon Paste Electrode (CTABCPE) illustrated reversible behavior by cyclic voltammetry (CV) in the detection of CPZ. The results showed that the electrocatalytic activity of CTAB modified carbon paste electrode (CTABMCPE) was more selective when compared to bare carbon paste electrode (CPE). The modified electrode showed good selectivity, stability and antifouling properties. This lab allowed students to investigate how to build a carbon paste electrode with a capillary tube and modify the electrode surface with a surfactant CTAB to detect CPZ in phosphate buffer solution.

Key Words: Computers in Chemistry; inorganic chemistry; electroanalytical chemistry; modified carbon paste electrode, surfactant; cetyltrimethylammonium bromide (CTAB); cyclic voltammetry; chlorpromazine (CPZ); inquiry-based lab; problem-based experiment

(*) Corresponding author. (E-mail: Suzanne.Lunsford@wright.edu)

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