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The Chemical Educator

ISSN: 1430-4171 (electronic version)

Table of Contents

Abstract Volume 18 (2013) pp 110-115
DOI 10.1007/s00897132479

Tamiflu: An Advanced Organic Chemistry Laboratory in Multi-Step Synthesis

Stephen R Sieck

Department of Chemistry, Grinnell College, 1116 8th Ave., Grinnell, IA 50112,
Received February 18, 2013. Accepted March 16, 2013.

Published: 17 May 2013

Abstract. The advanced chemistry laboratory course described focuses on a multi-step synthesis of Tamiflu as the central project. To accomplish this challenging laboratory successfully, three goals were prioritized: generating a research group environment through collaboration, building an appropriate knowledge base, and placing it into context.The class portion of the course is formatted into three categories to support the Tamiflu laboratory: a discussion-based comparative case-study approach, a traditional lecture style, and a medicinal chemistry section. The laboratory development, course background, student assessment, and course results are described.

Key Words: Laboratories and Demonstrations; analytical chemistry; ion exchange chromatography; titration

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