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The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 19
(2014) pp 351-353
Measuring Ibuprofen Quantities in Expired Over-the-Counter Tablets using HPLC and UV-VIS
Dan Y. Dong and Gordon G. Brown*
Department of Science and Mathematics, Coker College, Hartsville, SC 29550; gbrown@coker.edu
Received June 9, 2014. Accepted October 22, 2014.
Published: 28 November 2014
Abstract. In this laboratory experiment, high-performance liquid chromatography (HPLC) and ultraviolet-visible (UV-VIS) spectroscopy are used to measure expired and unexpired over-the-counter ibuprofen tablets. The laboratory, which is appropriate for an upper-level analytical chemistry course, introduces students to HPLC and addresses an interesting question from everyday life. Ultraviolet-visible (UV-VIS) spectroscopy is also performed on the same samples, and results are compared. The use of an instrumentation amplifier and Vernier software with legacy instrumentation is also described.
Key Words: Laboratories and Demonstrations; analytical chemistry; quantitative analysis; HPLC
(*) Corresponding author. (E-mail: gbrown@coker.edu)
Article in PDF format (123 KB) HTML format
Supporting Materials:
Instructions for students and instructors; part numbers and prices of Vernier equipment and software; sample data; and graphs of representative chromatograms (89 KB)
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