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The Chemical Educator

ISSN: 1430-4171 (electronic version)

Table of Contents

Abstract Volume 19 (2014) pp 351-353

Measuring Ibuprofen Quantities in Expired Over-the-Counter Tablets using HPLC and UV-VIS

Dan Y. Dong and Gordon G. Brown*

Department of Science and Mathematics, Coker College, Hartsville, SC 29550;
Received June 9, 2014. Accepted October 22, 2014.

Published: 28 November 2014

Abstract. In this laboratory experiment, high-performance liquid chromatography (HPLC) and ultraviolet-visible (UV-VIS) spectroscopy are used to measure expired and unexpired over-the-counter ibuprofen tablets. The laboratory, which is appropriate for an upper-level analytical chemistry course, introduces students to HPLC and addresses an interesting question from everyday life. Ultraviolet-visible (UV-VIS) spectroscopy is also performed on the same samples, and results are compared. The use of an instrumentation amplifier and Vernier software with legacy instrumentation is also described.

Key Words: Laboratories and Demonstrations; analytical chemistry; quantitative analysis; HPLC

(*) Corresponding author. (E-mail:

Article in PDF format (123 KB) HTML format

Supporting Materials:

Instructions for students and instructors; part numbers  and prices of  Vernier equipment and software; sample data; and graphs of representative chromatograms (89 KB)

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