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The Chemical Educator

ISSN: 1430-4171 (electronic version)

Table of Contents

Abstract Volume 21 (2016) pp 97-103

The Instrumental Analysis of Acetaminophen in Children’s Liquid Pain Relief Medicines by Cyclic Voltammetry (CV)

Wes E. Steiner* and Allyson P. Lesesne

Department of Chemistry and Biochemistry, Eastern Washington University, 226 Science Building, Cheney, WA 99004, USA,
Received February 22, 2016. Accepted May 2, 2016.

Published: 20 May 2016

Abstract. A modernized instrumental analysis laboratory employing a cost effective modular type of cyclic voltammetry system in combination with a laboratory report book (LRB), as outlined by the food and drug administration (FDA) for good laboratory practice (GLP) procedures, is presented here for the instrumental analysis of acetaminophen in children’s liquid pain relief medicines. Acetaminophen is considered one of the most common analgesics found in many pain relief medicines such as children’s liquid pain relief medicines where it tends to be in greater concentration than other analgesics. This article describes an approach to educators for the ready integration of cyclic voltammetry with that of a GLP procedure LRB for use in the undergraduate instrumental analysis laboratory course. However, even with this said, the common application of cyclic voltammetry in use as a favored classical electrochemical technique has not yet been fully incorporated, in combination with a GLP procedure LRB, into the undergraduate instruction laboratories as a didactic tool to enhance the learning process. To this end, this article works to inspire educators to use a current cost effective modular type of cyclic voltammetry instrumental analysis instrumentation in combination with a GLP procedure LRB to encourage undergraduate science, technology, engineering and mathematics (STEM) students to work together in two groups of pairs of two to qualitatively and quantitatively investigate the analysis of acetaminophen in children’s liquid pain relief medicines over a two day laboratory rotation schedule.

Key Words: Laboratories and Demonstrations; instrumental analysis; good laboratory practice; laboratory report book; acetaminophen; electrochemistry; cyclic voltammetry.

(*) Corresponding author. (E-mail:

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