Introducing Supercritical CO2 Extraction Into Undergraduate Laboratories

TCE

The Chemical Educator

ISSN: 1430-4171 (electronic version)

Table of Contents

Abstract Volume 22 (2017) pp 119-124

Introducing Supercritical CO₂ Extraction Into Undergraduate Laboratories

John Thompson, Shad Grunert, Natalia Sannikova, Hamel N. Tailor, and Nabyl Merbouh*

Department of Chemistry, Simon Fraser University 8888 University Drive Burnaby, B. C. V5A 1S6, Canada, nmerbouh@sfu.ca
Received January 12, 2017. Accepted May 18, 2017.

Published: 28 June 2017

Abstract. The applicability of supercritical fluid extraction (SFE) in an undergraduate laboratory setting is demonstrated in this paper through a series of experiments. Using a commercial supercritical carbon dioxide (SCCO₂) apparatus, the extraction of natural products was conducted from small trials to large scale with subsequent separation and purification of compounds of interest. When extraction is coupled with the analytical tools of NMR, GC-FID, and GC-MS, SFE can prove to be a valuable addition to the undergraduate teaching laboratory.

Key Words: Laboratories and Demonstrations; analytical chemistry, supercritical CO2; NMR Spectroscopy; GC-MS; natural products analysis

(*) Corresponding author. (E-mail: Suzanne.Lunsford@wright.edu )

Article in PDF format (610 KB) HTML format

Supporting Materials:

All GC-MS, and ¹H-NMR spectral data for all extracts described in this paper will be provided as supplementary material. (7.8 MB)