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The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 25
(2020) pp 139-145
Effects on Human Non-Small Lung Cancer Cell growth of Cu(II),
Au(III) and Re(I) Complexes Containing N-donor Pyridyl Ligands: A Senior Undergraduate Research Project
Kyle A. Koemm,† Michael DeBord,‡ Brian D. Wright,§ Patrick O. Wagers,‡ Matthew J. Panzner,‡ Michael Stromyer,‡ Wiley J. Youngs,‡ Sayandev Chatterjee, ** Samuel A. Bryan, ** Paul A. Bonvallet,† Sibrina Collins,*,††
†Department of Chemistry, The College of Wooster, Wooster, OH 44691;‡Department of Chemistry, The University of Akron, Akron, OH 44325; §Department of Radiology, University of Alabama School of Medicine, Birmingham, AL 35294; **Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, WA 99352; ††The Marburger STEM Center, Lawrence Technological University, Southfield, MI 48075, scollins@ltu.edu
Published: 17 August 2020
Abstract. Hands-on
synthetic laboratory experiences are critically important for undergraduate
chemistry majors. A senior undergraduate research experience at the College of
Wooster is presented in the current work. The inorganic complexes [Cu(phenan)2(NO3)2]
(1; phenan = phenanthridine) and
[Au(phenan)Cl3](2) were
prepared by metallation of the phenan ligand in a 1:1 CH3OH/CH2Cl2 mixture at room
temperature. Complex 1 is a new
inorganic coordination compound. The structures were confirmed by X-ray
crystallography. Complex 1 reveals a
distorted octahedral geometry around the central Cu (II) metal ion. In complex 2, the Au(III) atom exhibits a square
planar geometry. In addition, we investigated [Cu(dmeobpy)(H2O)2][NO3]2 (3; dmeobpy =
4,4’-dimethoxy-2,2’-bipyridine), [Cu(bap)(NO3)2](4; bap = 2,6-bis(azaindole)pyridine)
and [Re(CO)3(dmeobpy)Cl] (5).
The cytoxocities of 1-5, phenan,
dmeobpy, bap and cisplatin were evaluated against several human non-small cell
lung cancer cell lines (NCI-H1975, HCC827, NCI-H460, and NCI-A549). Compound 1 exhibited modest antitumor activity
against the HCC827 cell line, with an IC50 value of 19 µM. Compound 3 exhibits lower cytotoxic activity
than 1. The cytotoxic activity of
complex 5 (IC50 < 11
µM) is significantly greater than 1 and 3 against the H1975 cancer cell
line.
Key Words: Laboratories and Demonstrations; inorganic chemistry; coordination chemistry; crystal structure; lung cancer; cisplatin; phenanthriplatin; copper
(*) Corresponding author. (E-mail: scollins@ltu.edu)
Article in PDF format (305 KB) HTML format
Supporting Materials:
Synthetic
details, spectroscopic, X-ray diffraction for crystal structures 1-3,
and antitumor studies for complexes (PDF)
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