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The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 28
(2023) pp 122-126
Natural Product Mushroom Alkaloid Muscimol: Its Discovery and Syntheses
Crist N. Filer
Revvity, Inc, 940 Winter Street, Waltham, MA 02451, USA, Crist.Filer@revvity.com
Received August 28, 2023. Accepted August 28, 2023.
Published: 14 October 2023
Abstract. Muscimol is an isoxazole alkaloid isolated from the iconic mushroom Amanita muscaria. Although relatively small in size, muscimol has attracted great attention in the neurochemistry area based on its affinity for the GABAA receptor and its biological activity. The review relates the numerous synthetic approaches which have been designed to synthesize muscimol and also provided guidance to prepare valuable muscimol analogues.
Key Words: Laboratories and Demonstrations; organic chemistry;
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