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The Chemical Educator
ISSN: 1430-4171 (electronic version)
Abstract Volume 30
(2025) pp 12-15
An Appraisal of 5-Fluorouracil in Cancer Treatment
Hayden Dudek
The George Washington University School of Medicine, 2300 I St NW, Washington, DC 20052, hdudek00@gmail.com
Published: 14 January 2025
Abstract. 5-Fluorouracil is a uracil analog that has been used for over 65 years to treat a wide variety of neoplasms and diseases. It does so by disrupting normal nucleotide synthesis of both DNA and RNA, leading to tumor cell death [1]. This review aims to discuss the history of this medication, its mechanisms of action, and address the need for further research into increasing efficacy and preventing tumor resistance.
Key Words: Of Special Interest; biochemistry; chemotherapy; uracil analogs; assisted modulation; fluorination; cancer
(*) Corresponding author. (E-mail: hdudek00@gmail.com)
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